No, as long as it is taken with food. The vitamins and minerals in DHA ONE® with Folate are the highest quality available, and are forms specifically selected to reduce irritation and possible nausea. Also, we have included vitamin B-6 in DHA ONE® with Folate. Vitamin B-6 helps control nausea during pregnancy. Finally, our ultra-purified DHA means no fishy aftertaste that might contribute to nausea.